Evidence topic

Weight & Body Composition

Browse compounds studied for weight, appetite and metabolic outcomes.

How to read this page

Topic and body-area searches help discovery. They do not imply that evidence from one population, route or body site transfers to another.

Multiple Phase 3 human trials; investigational

Strong Phase III / approved-product evidence across multiple indication-specific out…

Strong Phase III and cardiovascular-outcomes evidence; authorised oral products are…

Phase 3 monotherapy evidence and development; investigational / not FDA-approved

Preclinical only — positive mouse metabolic data, no human therapeutic evidence

Human obesity development programme with large negative efficacy trial; unapproved

Established medicine/supplement context with indication-specific human evidence

Human trial underway; no published administered-drug efficacy result

Preclinical only; no therapeutic human exposure identified

Multiple human trials; Phase III PMM efficacy negative; narrow authorized rare-disea…

Preclinical only — compelling mouse metabolic data, no human therapeutic evidence

Historical Phase I human exposure; no established clinical efficacy programme / not…

Randomized Phase II human weight-loss evidence; unapproved

Approved medicine — extensive multi-outcome evidence, formulation/indication specific

FDA-approved U.S. weight-management medicine with strong Phase III evidence

Approved in China — jurisdiction specific

Published Phase 3 human evidence; investigational

Randomized Phase II human evidence across oral and subcutaneous formulations; invest…

Published Phase II evidence; Phase 3 development underway / investigational

Phase 3 development underway / investigational