Weight & Body Composition
Browse compounds studied for weight, appetite and metabolic outcomes.
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Topic and body-area searches help discovery. They do not imply that evidence from one population, route or body site transfers to another.
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RetatrutideRetatrutide
Phase II human evidence across weight and liver-fat outcomes / investigational
TirzepatideTirzepatide
Strong Phase III / approved-product evidence across multiple indication-specific out…
Semaglutide…Semaglutide (oral)
Strong Phase III and cardiovascular-outcomes evidence; authorised oral products are…
CagrilintideCagrilintide
Late-stage Phase III monotherapy evidence; investigational / not FDA-approved
5-Amino-1MQ5-Amino-1MQ
Preclinical only — positive mouse metabolic data, no human therapeutic evidence
AOD-9604AOD-9604
Human obesity development programme with large negative efficacy trial; unapproved
Levocarniti…Levocarnitine / L-carnitine
Established medicine/supplement context with indication-specific human evidence
MOTS-cMOTS-c
Human trial underway; no published administered-drug efficacy result
SLU-PP-332SLU-PP-332
Preclinical only; no therapeutic human exposure identified
ElamipretideElamipretide
Multiple human trials; Phase III PMM efficacy negative; narrow authorized rare-disea…
BAM15BAM15
Preclinical only — compelling mouse metabolic data, no human therapeutic evidence
SobetiromeSobetirome
Historical Phase I human exposure; no established clinical efficacy programme / not…
TesofensineTesofensine
Randomized Phase II human weight-loss evidence; unapproved
Semaglutide…Semaglutide (injectable)
Approved medicine — extensive multi-outcome evidence, formulation/indication specific
OrforglipronOrforglipron
FDA-approved U.S. weight-management medicine with strong Phase III evidence
MazdutideMazdutide
Approved in China — jurisdiction specific
SurvodutideSurvodutide
Phase 3 development / investigational
ZenagamtideZenagamtide
Randomized Phase II human evidence across oral and subcutaneous formulations; invest…
Maridebart…Maridebart cafraglutide
Strong Phase II human evidence; investigational
PemvidutidePemvidutide
Phase 3 development / investigational