Obesity, insulin resistance and metabolic research
Human evidence
No therapeutic human trial evidence was identified.
Regulatory status
No FDA/EMA-approved medicine identified.
Main limitations
Human efficacy, dose, therapeutic window, chronic safety or suitability as an oral lifestyle compound.
Safety
Mitochondrial uncoupling is intrinsically safety-sensitive; human therapeutic window, cardiac/thermal risks and chronic toxicity are unknown.
i
No therapeutic human trial evidence was identified.
What the evidence actually supports
✓Treat as high-interest preclinical science, not a lifestyle treatment.
What is not established / key limitations
×No human clinical trial evidence identified.
Selected study & evidence records
Discovery of BAM15 mitochondrial uncoupler
2014 · Preclinical mechanistic/animal study
BAM15 uncoupled mitochondrial respiration without the same plasma-membrane depolarization seen with some comparator uncouplers and showed mouse bioactivity.
Mitochondrial uncoupling is intrinsically safety-sensitive; human therapeutic window, cardiac/thermal risks and chronic toxicity are unknown.
Mitochondrial uncoupling is intrinsically safety-sensitive; human therapeutic window, thermal/cardiac risk and chronic toxicity are unknown despite preclinical selectivity claims.
Technical details
Mechanism / biologyMitochondrial protonophore that increases energy expenditure by partially uncoupling oxidative phosphorylation in experimental models.
Route / formulation boundaryThis is not a peptide; commercial oral products have no established clinical validation.
Identity / data-quality noteUse the canonical compound identity and studied formulation when interpreting evidence.
Dosing evidence statusDosing research conclusion recorded. No human systemic administration regimen identified; human-derived-cell and preclinical work do not establish a human dose or safety window.
Evidence rule: WhichPeps keeps human, animal, laboratory, regulatory and product/formulation evidence distinct. Common names help people find the page; they do not change the underlying scientific identity.
