WhichPeps
Definitions

Evidence Glossary

Plain-language definitions for the evidence terms and classifications used across WhichPeps.

Evidence classifications

Approved medicine — product/indication specific

Strong clinical/regulatory evidence exists for one or more authorised products and defined indications. · State the authorised indication and product; explicitly separate unverified non-authorised products.

Approved medicine in US — narrow indication

FDA approval exists for a narrowly defined use/product. · Do not broaden the approval to wellness, performance or generic research vials.

Phase 2 human evidence / investigational

Controlled human efficacy data exist but the compound remains investigational. · Report study population, endpoints and adverse events; do not say 'approved' or 'proven'.

Early human pharmacology; unapproved

Human exposure/PK/PD studies exist but clinical outcomes are not established. · Explain what changed biologically, not that it treats a condition.

Limited/regional human evidence

Small, older or region-specific studies exist with limited independent replication. · Use cautious wording and highlight study-quality/generalizability limitations.

Primarily preclinical / extremely limited human evidence

Most evidence is animal/cell based with little human clinical data. · Lead with the evidence limitation before describing proposed effects.

Preclinical only

No meaningful therapeutic human evidence identified. · Describe laboratory/animal findings only; never convert them into a human benefit claim.

No direct human drug-exposure evidence identified

Human endogenous/biomarker data may exist, but administered-drug evidence is absent. · State clearly that endogenous biology is not evidence for injected/supplemented use.

Blend — no direct clinical evidence

The named commercial combination has not been clinically tested as a blend. · Summarise components separately and state that synergy/safety of the blend is unestablished.

Identity/formulation unresolved

Active ingredient or exact blend composition cannot be verified from source. · Do not publish benefits until label/COA/manufacturer information is obtained.

Support item

Diluent/reconstitution/lab item rather than therapeutic active. · Information page only; no therapeutic-benefit language.