Study record · BAM15
Discovery of BAM15 mitochondrial uncoupler
BAM15 uncoupled mitochondrial respiration without the same plasma-membrane depolarization seen with some comparator uncouplers and showed mouse bioactivity.
Key result
BAM15 uncoupled mitochondrial respiration without the same plasma-membrane depolarization seen with some comparator uncouplers and showed mouse bioactivity.
Study details
Study designPreclinical mechanistic/animal study
PopulationCells and mice
RoutePreclinical
Regimen / exposureBAM15
DurationAcute experimental exposure
ComparatorComparator uncouplers / controls
Primary endpoint / questionMitochondrial uncoupling and ischemia-reperfusion protection
Safety resultNo human therapeutic safety data.
Key limitationsDiscovery/preclinical study; mitochondrial uncoupling is intrinsically safety-sensitive.
Registry / identifierPMID 24634817