Discovery of BAM15 mitochondrial uncoupler
BAM15 uncoupled mitochondrial respiration without the same plasma-membrane depolarization seen with some comparator uncouplers and showed mouse bioactivity.
What this study tells us
This was preclinical research in animals and/or laboratory models. It can show a biological signal, but it cannot prove the same benefit, dose or safety in people.
Cells and mice
Animal or laboratory sample size is not captured in this public summary.
BAM15 uncoupled mitochondrial respiration without the same plasma-membrane depolarization seen with some comparator uncouplers and showed mouse bioactivity.
Discovery/preclinical study; mitochondrial uncoupling is intrinsically safety-sensitive.
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Key result
BAM15 uncoupled mitochondrial respiration without the same plasma-membrane depolarization seen with some comparator uncouplers and showed mouse bioactivity.