Study record · BAM15
BAM15-mediated uncoupling in diet-induced obesity
BAM15 protected mice against diet-induced weight gain and improved metabolic measures.
Key result
BAM15 protected mice against diet-induced weight gain and improved metabolic measures.
Study details
Study designPreclinical animal efficacy study
PopulationDiet-induced obese mice
RoutePreclinical
Regimen / exposureBAM15
DurationExperimental treatment
ComparatorVehicle/control
Primary endpoint / questionBody weight, composition and glycaemic control
Safety resultNo human therapeutic safety data.
Key limitationsMouse efficacy does not establish a safe human therapeutic window; uncouplers can have serious toxicity if energy dissipation is excessive.
Registry / identifierPMID 32519812