Animal / preclinical evidence · BAM15
BAM15-mediated uncoupling in diet-induced obesity
BAM15 protected mice against diet-induced weight gain and improved metabolic measures.
Quick read
Animal / preclinical evidence
What this study tells us
This was preclinical research in animals and/or laboratory models. It can show a biological signal, but it cannot prove the same benefit, dose or safety in people.
Who was studied?
Diet-induced obese mice
How many?
Animal or laboratory sample size is not captured in this public summary.
What happened?
BAM15 protected mice against diet-induced weight gain and improved metabolic measures.
What stops us overclaiming?
Mouse efficacy does not establish a safe human therapeutic window; uncouplers can have serious toxicity if energy dissipation is excessive.
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Key result
BAM15 protected mice against diet-induced weight gain and improved metabolic measures.
Study details
Study designPreclinical animal efficacy study
PopulationDiet-induced obese mice
RoutePreclinical
Regimen / exposureBAM15
DurationExperimental treatment
ComparatorVehicle/control
Primary endpoint / questionBody weight, composition and glycaemic control
Safety resultNo human therapeutic safety data.
Key limitationsMouse efficacy does not establish a safe human therapeutic window; uncouplers can have serious toxicity if energy dissipation is excessive.
Registry / identifierPMID 32519812