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SLU-PP-332

Synthetic small-molecule estrogen-related receptor agonist

Exercise-mimeticmetabolism and obesity…
Generic peptide vial illustrationSLU-PP-332
Entity typeSmall molecule
Evidence reviewed2026-09-18
Canonical recordSLUPP332
Page updated2026-09-20
Evidence profilePreclinical only; no therapeutic human exposure identified
Human evidenceNone established
Regulatory statusNo FDA/EMA approval identified
Choose your depthStart simple, then open the evidence or technical detail only if you need it.
Quick answerPlain languageEvidenceOutcomes and studiesStudiesPrimary recordsTechnicalMechanism, route and identifiers

In plain English

30-second evidence answer

What does the evidence mean in simple terms?

All therapeutic evidence for SLU-PP-332 is still preclinical. Animal studies are scientifically interesting, but we did not identify established human treatment studies, so we do not yet know whether it works or is safe in people.

Still uncertain: Human benefit, dose, how the body handles it, interactions, exercise effects, weight loss and long-term safety.

New to terms such as “preclinical”, “randomized” or “investigational”? Use the plain-English glossary →

What does the evidence mean in simple terms? table
What is it?Synthetic small-molecule estrogen-related receptor agonist
Entity typeSmall molecule
Research focusExercise-mimetic, metabolism and obesity research
Human evidenceNo therapeutic human administration evidence identified. A 2026 human-liver S9 study addresses metabolism/detection, not clinical exposure.
Regulatory statusNo FDA/EMA-approved medicine identified.
Main limitationsHuman exercise enhancement, weight loss, dose, pharmacokinetics, interactions or long-term safety.
SafetyHuman PK, toxicity, carcinogenicity/reproductive safety and therapeutic window are unknown.
Evidence reviewed2026-09-18
i
No therapeutic human administration evidence identified. A 2026 human-liver S9 study addresses metabolism/detection, not clinical exposure.
Outcome-level evidence

Evidence is not one score.

Each record below answers a narrower question about an outcome, population or context. Evidence status and the study finding are shown separately so strong evidence is not mistaken for a positive effect.

How to read this →

Exercise endurance / exercise mimetic effect

Preclinical evidence
Preclinical animal evidence

Context: Mouse models

Finding: Strong mouse mechanism/performance signal.

Safety / tolerability context: No human endurance, dose, PK or safety data.

Verified 2026-09-18Primary source ↗

Fat oxidation / metabolic syndrome

Preclinical evidence
Preclinical animal evidence

Context: Mouse metabolic models

Finding: Positive preclinical metabolic signal.

Uncertainty / evidence gap: No established human weight-loss effect or safe therapeutic window.

Evidence rule: an outcome-specific evidence label is not a recommendation, a safety rating or an overall score for the compound.

Evidence synthesis

  • ✓Strong mouse mechanism/performance signal.
  • ✓Positive preclinical metabolic signal.

Important limitations

  • !Mouse intraperitoneal dosing cannot be converted to a human protocol.
  • !ERR agonism and exercise-mimetic biology are still translational research.

Selected study & evidence records

SLU-PP-332 exercise-mimetic study

2023 · Preclinical mechanistic/animal study

SLU-PP-332 increased oxidative muscle features and enhanced exercise endurance in mice through ERR-dependent signalling.

Study detail → Primary source ↗

SLU-PP-332 metabolic syndrome study

2023 · Preclinical animal study

The study reported increased energy expenditure/fat oxidation and improved metabolic phenotypes in mice.

Study detail → Primary source ↗

In-vitro human liver metabolism study for SLU-PP-332

2026 · In-vitro human-derived metabolism / anti-doping study

Human-derived liver metabolism work identified metabolites relevant to detection, but did not administer the compound to people.

Study detail → Primary source ↗

Safety and unknowns

Human PK, toxicity, carcinogenicity/reproductive safety and therapeutic window are unknown.

Human pharmacokinetics, therapeutic window, organ toxicity, cardiovascular risk and long-term safety are unknown.

Technical details

Mechanism / biologyPan-ERR agonist that activates transcriptional programmes associated with oxidative metabolism/exercise adaptation in experimental models.
Route / formulation boundaryThis is a small molecule, not a peptide. Oral commercial capsules are not validated by preclinical papers.
Identity / data-quality noteUse the canonical compound identity and studied formulation when interpreting evidence.
Study / label regimen evidenceStudy-regimen evidence reviewed. No human dosing regimen identified; current literature remains preclinical, medicinal-chemistry and analytical.
Identifiers & alternate namesSLU PP 332 · SLUPP332 · Slu-PP 332

Source depth & provenance

WhichPeps does not rely on a single headline study when the evidence base is broader. Primary research, registries, regulators and supporting records are kept distinct.

3structured study records
2outcome records
8linked source records

How to read these counts: they show evidence coverage, not evidence strength. One large, well-designed study can be more informative than several weak or indirect records.

Show supporting and discovery sources

Study pages above contain the records used for public evidence summaries. The links below include supporting, regulatory and literature-discovery sources; a registry or search result is not treated as proof of benefit.

Evidence rule: WhichPeps keeps human, animal, laboratory, regulatory and product/formulation evidence distinct. Common names help people find the page; they do not change the underlying scientific identity.