WhichPeps

5-Amino-1MQ

Small-molecule NNMT inhibitor

Obesityadiposity and metabolic…
Generic peptide vial illustration5-Amino-1MQ
Evidence levelPreclinical only
Human evidenceNone established
Regulatory statusNo FDA/EMA approval identified

What you need to know in 20 seconds

What is it?Small-molecule NNMT inhibitor
Research focusObesity, adiposity and metabolic research
Human evidenceNo established therapeutic human trial evidence was identified in this review.
Regulatory statusNo FDA/EMA-approved therapeutic product identified.
Main limitationsHuman weight-loss efficacy, dose, long-term safety, cardiovascular risk or chronic toxicity.
SafetyHuman pharmacokinetics, toxicity and long-term safety are not established.
i
No established therapeutic human trial evidence was identified in this review.

What the evidence actually supports

  • ✓Keep as an experimental metabolic compound, not a peptide or human-proven weight-loss drug.

What is not established / key limitations

  • ×No human efficacy or human therapeutic dose established.

Selected study & evidence records

NNMT inhibition with 5-Amino-1MQ in diet-induced obese mice

2018 · Preclinical cell and animal study

NNMT inhibition reduced obesity-related measures in mice and altered metabolic pathways.

Study detail → Primary source ↗

5A1MQ metabolic effects in diet-induced obese mice

2024 · Preclinical animal PK/efficacy study

5A1MQ dose-dependently limited weight/fat gain and improved glucose/insulin and liver measures in mice.

Study detail → Primary source ↗

Safety and unknowns

Human pharmacokinetics, toxicity and long-term safety are not established.

Human pharmacokinetics, therapeutic window, chronic toxicity and interaction profile are not established.

Technical details

Mechanism / biologyInhibits nicotinamide N-methyltransferase (NNMT), altering methyl/nicotinamide metabolism in experimental models.
Route / formulation boundary5-Amino-1MQ is a small-molecule research compound, not a peptide.
Identity / data-quality noteUse the canonical compound identity and studied formulation when interpreting evidence.
Dosing evidence statusDosing research conclusion recorded. No published human interventional dosing identified; numerical exposures in the primary literature are preclinical.
Identifiers & alternate names5 Amino 1Mq

Evidence rule: WhichPeps keeps human, animal, laboratory, regulatory and product/formulation evidence distinct. Common names help people find the page; they do not change the underlying scientific identity.