Animal / preclinical evidence · 5-Amino-1MQ
NNMT inhibition with 5-Amino-1MQ in diet-induced obese mice
NNMT inhibition reduced obesity-related measures in mice and altered metabolic pathways.
Quick read
Animal / preclinical evidence
What this study tells us
This was preclinical research in animals and/or laboratory models. It can show a biological signal, but it cannot prove the same benefit, dose or safety in people.
Who was studied?
Cultured adipocytes and diet-induced obese mice
How many?
No participant count — this was laboratory or analytical research.
What happened?
NNMT inhibition reduced obesity-related measures in mice and altered metabolic pathways.
What stops us overclaiming?
Animal efficacy cannot establish human weight-loss benefit or dosing.
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Key result
NNMT inhibition reduced obesity-related measures in mice and altered metabolic pathways.
Study details
Study designPreclinical cell and animal study
PopulationCultured adipocytes and diet-induced obese mice
RoutePreclinical
Regimen / exposureSmall-molecule NNMT inhibitor exposure
DurationExperimental course
ComparatorVehicle/control groups
Primary endpoint / questionBody weight, adiposity and metabolic markers
Safety resultNo human safety dataset generated.
Key limitationsAnimal efficacy cannot establish human weight-loss benefit or dosing.
Registry / identifierPMID 29155147