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Menotropins (human menopausal gonadotropin)

Gonadotropin mixture (FSH/LH activity)

Assisted reproduction a…
Generic peptide vial illustrationMenotropins (human menopausal gonadotropin)
Entity typeGonadotropin biologic mixture
Evidence reviewed2026-09-18
Canonical recordHMG
Page updated2026-09-20
Evidence profileApproved medicine — strong specialist fertility evidence
Human evidenceSubstantial
Regulatory statusLicensed products exist
Choose your depthStart simple, then open the evidence or technical detail only if you need it.
Quick answerPlain languageEvidenceOutcomes and studiesStudiesPrimary recordsTechnicalMechanism, route and identifiers

In plain English

30-second evidence answer

What does the evidence mean in simple terms?

Menotropins are prescription fertility medicines used in specialist care. They have established human evidence for defined fertility treatments, but they normally require close medical monitoring.

Still uncertain: The evidence does not support unrelated use or unsupervised use outside specialist fertility care.

New to terms such as “preclinical”, “randomized” or “investigational”? Use the plain-English glossary →

What does the evidence mean in simple terms? table
What is it?Gonadotropin mixture (FSH/LH activity)
Entity typeGonadotropin biologic mixture
Research focusAssisted reproduction and fertility
Human evidenceLicensed menotropin medicines have substantial randomized specialist-fertility evidence, including large IVF/ICSI trials and high-responder studies.
Regulatory statusLicensed menotropin products exist, including authorised fertility medicines. An unverified product is not automatically equivalent to a licensed medicine.
Main limitationsUse outside fertility indications or without specialist ovarian/testicular monitoring.
SafetyMajor risks include ovarian hyperstimulation syndrome, multifetal gestation, thromboembolic and other reproductive-treatment complications; specialist monitoring is standard.
Evidence reviewed2026-09-18
i
Licensed menotropin medicines have substantial randomized specialist-fertility evidence, including large IVF/ICSI trials and high-responder studies.
Outcome-level evidence

Evidence is not one score.

Each record below answers a narrower question about an outcome, population or context. Evidence status and the study finding are shown separately so strong evidence is not mistaken for a positive effect.

How to read this →

Ongoing pregnancy in IVF/ICSI

Human evidence
Large randomized Phase III comparative evidence

Context: Women undergoing IVF/ICSI

Finding: Licensed menotropin therapy has substantial controlled efficacy evidence in specialist fertility care.

Uncertainty / evidence gap: No basis to extrapolate this evidence to non-fertility or unsupervised hormone use.

Verified 2026-09-18Primary source ↗

High-responder fertility efficacy and OHSS risk

Human evidence
Randomized noninferiority human evidence

Context: Predicted high ovarian responders

Finding: Efficacy was comparable in this selected population.

Safety / tolerability context: OHSS and early pregnancy loss were lower with HP-hMG in this trial.

Verified 2026-09-18Primary source ↗
Evidence rule: an outcome-specific evidence label is not a recommendation, a safety rating or an overall score for the compound.

Evidence synthesis

  • ✓Licensed menotropin therapy has substantial controlled efficacy evidence in specialist fertility care.
  • ✓Efficacy was comparable in this selected population.

Important limitations

  • !Product, IU potency and protocol are specialist/indication specific.
  • !High-responder ART population.

Selected study & evidence records

Highly purified menotropin versus recombinant FSH in IVF/ICSI

2002 · Multinational randomized parallel-group Phase III comparative trial · n=781

Ongoing pregnancy rates were similar (about 25% with HP-hMG vs 22% with recombinant FSH in the per-protocol analysis).

Study detail → Primary source ↗

Highly purified hMG versus recombinant FSH in predicted high responders

2020 · Randomized, assessor-blinded, parallel-group noninferiority trial · n=620

Fresh ongoing pregnancy was noninferior; cumulative live-birth rates were similar.

Study detail → Primary source ↗

Safety and unknowns

Major risks include ovarian hyperstimulation syndrome, multifetal gestation, thromboembolic and other reproductive-treatment complications; specialist monitoring is standard.

Technical details

Mechanism / biologyProvides follicle-stimulating and luteinising hormone activity to stimulate gonadal function.
Route / formulation boundaryIU potency and biologic-product quality are formulation-specific.
Identity / data-quality noteUse the canonical compound identity and studied formulation when interpreting evidence.
Study / label regimen evidenceVerified study/label regimen evidence is available. UK licensed menotrophin dosing example. Open descriptive regimen evidence →
Identifiers & alternate namesHMG · hMG · Menotrophin

Source depth & provenance

WhichPeps does not rely on a single headline study when the evidence base is broader. Primary research, registries, regulators and supporting records are kept distinct.

2structured study records
2outcome records
7linked source records

How to read these counts: they show evidence coverage, not evidence strength. One large, well-designed study can be more informative than several weak or indirect records.

Show supporting and discovery sources

Study pages above contain the records used for public evidence summaries. The links below include supporting, regulatory and literature-discovery sources; a registry or search result is not treated as proof of benefit.

Evidence rule: WhichPeps keeps human, animal, laboratory, regulatory and product/formulation evidence distinct. Common names help people find the page; they do not change the underlying scientific identity.