Study record · Menotropins (human menopausal gonadotropin)
Highly purified menotropin versus recombinant FSH in IVF/ICSI
Ongoing pregnancy rates were similar (about 25% with HP-hMG vs 22% with recombinant FSH in the per-protocol analysis).
Key result
Ongoing pregnancy rates were similar (about 25% with HP-hMG vs 22% with recombinant FSH in the per-protocol analysis).
Study details
Study designMultinational randomized parallel-group Phase III comparative trial
PhasePhase III
PopulationWomen undergoing IVF/ICSI
Sample size781
RouteInjection
Regimen / exposureControlled ovarian stimulation with highly purified hMG or recombinant FSH per protocol
DurationOne treatment cycle
ComparatorRecombinant FSH
Primary endpoint / questionOngoing pregnancy and safety
Safety resultOHSS, miscarriage, adverse events and injection-site reactions were broadly similar between groups.
Key limitationsFertility-specialist population and protocol; not general endocrine use.
Registry / identifierPMID 12215327