Study record · Menotropins (human menopausal gonadotropin)
Highly purified hMG versus recombinant FSH in predicted high responders
Fresh ongoing pregnancy was noninferior; cumulative live-birth rates were similar.
Key result
Fresh ongoing pregnancy was noninferior; cumulative live-birth rates were similar.
Study details
Study designRandomized, assessor-blinded, parallel-group noninferiority trial
PopulationWomen predicted to be high ovarian responders
Sample size620
RouteInjection
Regimen / exposureControlled ovarian stimulation with HP-hMG or recombinant FSH
DurationART cycle + transfers within 6 months
ComparatorRecombinant FSH
Primary endpoint / questionOngoing pregnancy, cumulative live birth, OHSS and pregnancy loss
Safety resultHP-hMG was associated with lower OHSS and lower early pregnancy-loss rates in this high-responder population.
Key limitationsPopulation-specific fertility protocol; cannot be extrapolated outside specialist reproductive care.
Registry / identifierPMID 32416978 / NCT02554279