Historical sobetirome Phase I single- and multiple-dose study (reported in peer-reviewed reviews)
Peer-reviewed reviews report LDL-C reductions up to 22% after single-dose exposure and up to 41% after the two-week multiple-dose phase.
What this study tells us
This record summarizes a historical randomized Phase I study as reported in later peer-reviewed reviews. The primary full clinical report was not located, so the result is useful context but not equivalent to direct inspection of the original trial publication.
Adult participants
n=32 single-dose; 24 multiple-dose
Peer-reviewed reviews report LDL-C reductions up to 22% after single-dose exposure and up to 41% after the two-week multiple-dose phase.
Primary full clinical report was not located; the result is described in later peer-reviewed reviews and historical meeting reporting. Long-term outcomes are unknown.
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Key result
Peer-reviewed reviews report LDL-C reductions up to 22% after single-dose exposure and up to 41% after the two-week multiple-dose phase.