Human evidence record · Glutathione
Effects of oral glutathione supplementation on systemic oxidative stress biomarkers
No significant between-group changes in measured oxidative-stress biomarkers or glutathione indices.
Quick read
Human evidence record
What this study tells us
Participants were assigned to comparison groups by chance, usually with placebo and/or blinding to reduce bias. This is a strong design for testing cause and effect, but the population, duration and endpoints still limit what can be concluded.
Who was studied?
Healthy adult volunteers
How many?
n=40
What happened?
No significant between-group changes in measured oxidative-stress biomarkers or glutathione indices.
What stops us overclaiming?
Short trial in healthy adults; does not address other populations or routes.
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Key result
No significant between-group changes in measured oxidative-stress biomarkers or glutathione indices.
Study details
Study designRandomized, double-blind, placebo-controlled clinical trial
PopulationHealthy adult volunteers
Sample size40
RouteOral
Regimen / exposure500 mg twice daily
Duration4 weeks
ComparatorPlacebo
Primary endpoint / questionOxidative-stress biomarkers and glutathione status
Safety resultNo major safety signal highlighted in the abstract.
Key limitationsShort trial in healthy adults; does not address other populations or routes.
Registry / identifierPMID 21875351