Animal / preclinical evidence · TB-500
Effects of BPC-157 and TB-500 on Achilles tendon healing in rats
TB-500 significantly improved maximum load-to-failure versus control and improved several histologic measures.
Quick read
Animal / preclinical evidence
What this study tells us
This was preclinical research in animals and/or laboratory models. It can show a biological signal, but it cannot prove the same benefit, dose or safety in people.
Who was studied?
Male Sprague-Dawley rats after Achilles tendon transection and repair
How many?
n=32
What happened?
TB-500 significantly improved maximum load-to-failure versus control and improved several histologic measures.
What stops us overclaiming?
Eight rats per group; exploratory model; no human translation established.
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Key result
TB-500 significantly improved maximum load-to-failure versus control and improved several histologic measures.
Study details
Study designRandomized animal experiment
PhasePreclinical
PopulationMale Sprague-Dawley rats after Achilles tendon transection and repair
Sample size32
RouteIntraperitoneal
Regimen / exposureTB-500 60 microg/kg/day; separate BPC-157 and combination arms
Duration4 weeks
ComparatorVehicle, BPC-157, combination
Primary endpoint / questionBiomechanics, histology, collagen organization
Safety resultAnimal study; human safety cannot be inferred.
Key limitationsEight rats per group; exploratory model; no human translation established.
Registry / identifierPMID 42542926