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Human evidence record · Semax

Semax during rehabilitation after ischemic stroke

Semax exposure was associated with higher BDNF and faster/final Barthel-index improvement in the study groups.

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Human evidence record

What this study tells us

This study compared groups, which is more informative than an uncontrolled report. The amount of confidence still depends on how the groups were formed, how outcomes were measured and how well bias was controlled.

Who was studied?

Patients after ischemic stroke

How many?

n=110

What happened?

Semax exposure was associated with higher BDNF and faster/final Barthel-index improvement in the study groups.

What stops us overclaiming?

Regional study, subgroup design and rehabilitation timing complicate causal interpretation; not a healthy-person cognition trial.

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Key result

Semax exposure was associated with higher BDNF and faster/final Barthel-index improvement in the study groups.

Study details

Study designClinical comparative rehabilitation study
PhaseNot stated
PopulationPatients after ischemic stroke
Sample size110
RouteIntranasal
Regimen / exposure6000 micrograms/day for 10 days, two courses separated by 20 days
DurationTwo treatment courses
ComparatorSemax-negative rehabilitation subgroups
Primary endpoint / questionBDNF, motor performance and Barthel index
Safety resultNo modern large international safety programme generated.
Key limitationsRegional study, subgroup design and rehabilitation timing complicate causal interpretation; not a healthy-person cognition trial.
Registry / identifierPMID 29798983
Evidence verified2026-09-18