Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1)
Mean weight change -14.9% with semaglutide vs -2.4% placebo; 86.4% achieved ≥5% loss.
What this study tells us
Participants were assigned to comparison groups by chance, usually with placebo and/or blinding to reduce bias. This is a strong design for testing cause and effect, but the population, duration and endpoints still limit what can be concluded.
Adults with obesity or qualifying overweight without diabetes
n=1961
Mean weight change -14.9% with semaglutide vs -2.4% placebo; 86.4% achieved ≥5% loss.
Trial population excludes diabetes; sponsored trial; long-term maintenance beyond trial required further study.
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Key result
Mean weight change -14.9% with semaglutide vs -2.4% placebo; 86.4% achieved ≥5% loss.