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Human evidence record ยท Oxytocin

Long-term intranasal oxytocin for female sexual dysfunction

Sexual function improved during both oxytocin and placebo periods, with no statistically significant treatment effect.

Quick read
Human evidence record

What this study tells us

Participants were assigned to comparison groups by chance, usually with placebo and/or blinding to reduce bias. This is a strong design for testing cause and effect, but the population, duration and endpoints still limit what can be concluded.

Who was studied?

Pre- and postmenopausal women with sexual dysfunction

How many?

n=30

What happened?

Sexual function improved during both oxytocin and placebo periods, with no statistically significant treatment effect.

What stops us overclaiming?

Small sample with large placebo/context effect; does not establish oxytocin as an effective treatment for female sexual dysfunction.

Need help with terms such as randomized, placebo, endpoint or sample size? Open the glossary โ†’

Key result

Sexual function improved during both oxytocin and placebo periods, with no statistically significant treatment effect.

Study details

Study designRandomized, double-blind, placebo-controlled crossover trial
PopulationPre- and postmenopausal women with sexual dysfunction
Sample size30
RouteIntranasal
Regimen / exposure32 IU within 50 minutes before intercourse
DurationTwo 8-week periods with 2-week washout
ComparatorPlacebo
Primary endpoint / questionFemale Sexual Function Index and sexual-distress / quality-of-life measures
Safety resultNo broad safety conclusion should be drawn from this small crossover trial.
Key limitationsSmall sample with large placebo/context effect; does not establish oxytocin as an effective treatment for female sexual dysfunction.
Registry / identifierPMID 26151620 / NCT02229721