Study record · Oxytocin
Long-term intranasal oxytocin for female sexual dysfunction
Sexual function improved during both oxytocin and placebo periods, with no statistically significant treatment effect.
Key result
Sexual function improved during both oxytocin and placebo periods, with no statistically significant treatment effect.
Study details
Study designRandomized, double-blind, placebo-controlled crossover trial
PopulationPre- and postmenopausal women with sexual dysfunction
Sample size30
RouteIntranasal
Regimen / exposure32 IU within 50 minutes before intercourse
DurationTwo 8-week periods with 2-week washout
ComparatorPlacebo
Primary endpoint / questionFemale Sexual Function Index and sexual-distress / quality-of-life measures
Safety resultNo broad safety conclusion should be drawn from this small crossover trial.
Key limitationsSmall sample with large placebo/context effect; does not establish oxytocin as an effective treatment for female sexual dysfunction.
Registry / identifierPMID 26151620 / NCT02229721