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Review / evidence synthesis · Oxytocin

Intranasal oxytocin for psychiatric symptoms: systematic review and meta-analysis

Pooled standardized effect was small and not statistically significant (g≈0.17, 95% CI crossing zero) with high heterogeneity.

Quick read
Review / evidence synthesis

What this study tells us

This study reviewed or combined evidence from multiple studies. It can show the overall direction of a field, but its conclusion still depends on the quality and relevance of the studies it included.

Who was studied?

Participants with mental disorders

How many?

n=1922

What happened?

Pooled standardized effect was small and not statistically significant (g≈0.17, 95% CI crossing zero) with high heterogeneity.

What stops us overclaiming?

Heterogeneous diagnoses, doses, endpoints and study quality; does not support a simple general cognitive or mood-enhancement claim.

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Key result

Pooled standardized effect was small and not statistically significant (g≈0.17, 95% CI crossing zero) with high heterogeneity.

Study details

Study designSystematic review and meta-analysis of double-blind RCTs
PopulationParticipants with mental disorders
Sample size1922
RouteMostly intranasal across included trials
Regimen / exposureVaried across 42 trials
DurationVaried
ComparatorPlacebo
Primary endpoint / questionOverall psychiatric symptom effects
Safety resultSafety reporting varied across trials.
Key limitationsHeterogeneous diagnoses, doses, endpoints and study quality; does not support a simple general cognitive or mood-enhancement claim.
Registry / identifierPMID 42134427