Study record · Oxytocin
Intranasal oxytocin for psychiatric symptoms: systematic review and meta-analysis
Pooled standardized effect was small and not statistically significant (g≈0.17, 95% CI crossing zero) with high heterogeneity.
Key result
Pooled standardized effect was small and not statistically significant (g≈0.17, 95% CI crossing zero) with high heterogeneity.
Study details
Study designSystematic review and meta-analysis of double-blind RCTs
PopulationParticipants with mental disorders
Sample size1922
RouteMostly intranasal across included trials
Regimen / exposureVaried across 42 trials
DurationVaried
ComparatorPlacebo
Primary endpoint / questionOverall psychiatric symptom effects
Safety resultSafety reporting varied across trials.
Key limitationsHeterogeneous diagnoses, doses, endpoints and study quality; does not support a simple general cognitive or mood-enhancement claim.
Registry / identifierPMID 42134427