Study record · NAD+
NAD+ supplementation for anti-aging and wellness: PRISMA-guided systematic review
Oral NR/NMN usually showed biochemical target engagement, but clinically meaningful outcomes were heterogeneous; no eligible IV/IM NAD+ outcome trial for.
Key result
Oral NR/NMN usually showed biochemical target engagement, but clinically meaningful outcomes were heterogeneous; no eligible IV/IM NAD+ outcome trial for anti-ageing/wellness was identified.
Study details
Study designSystematic review
PopulationHuman and rodent intervention literature
Sample size113 studies (33 human; 80 rodent)
RouteMixed
Regimen / exposureNR, NMN, NAD+ and related interventions across included studies
DurationStudies through Oct 2025
ComparatorVaried
Primary endpoint / questionClinical evidence for NAD-related anti-ageing/wellness interventions
Safety resultSafety varied by intervention; direct parenteral NAD+ outcome evidence was too sparse for a robust benefit-risk conclusion.
Key limitationsDifferent NAD-related molecules and routes cannot be treated as interchangeable.
Registry / identifierPMID 41655607