NAD+ supplementation for anti-aging and wellness: PRISMA-guided systematic review
Oral NR/NMN usually showed biochemical target engagement, but clinically meaningful outcomes were heterogeneous; no eligible IV/IM NAD+ outcome trial for anti-ageing/wellness was identified.
What this study tells us
This study reviewed or combined evidence from multiple studies. It can show the overall direction of a field, but its conclusion still depends on the quality and relevance of the studies it included.
Human and rodent intervention literature
n=113 studies (33 human; 80 rodent)
Oral NR/NMN usually showed biochemical target engagement, but clinically meaningful outcomes were heterogeneous; no eligible IV/IM NAD+ outcome trial for anti-ageing/wellness was identified.
Different NAD-related molecules and routes cannot be treated as interchangeable.
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Key result
Oral NR/NMN usually showed biochemical target engagement, but clinically meaningful outcomes were heterogeneous; no eligible IV/IM NAD+ outcome trial for anti-ageing/wellness was identified.