MOTS-c is an exercise-induced mitochondrial-encoded regulator of physical decline
Exercise increased endogenous MOTS-c in muscle and circulation in the human component.
What this study tells us
The human component measured the body’s own MOTS-c response before and after exercise; separate preclinical experiments explored biology. No exogenous MOTS-c was administered to the human participants, so this is not a human treatment-efficacy study.
Young male exercise participants in human component
n=10
Exercise increased endogenous MOTS-c in muscle and circulation in the human component.
Endogenous peptide response is not evidence that injected/supplemented MOTS-c is effective or safe in humans.
Need help with terms such as randomized, placebo, endpoint or sample size? Open the glossary →
Key result
Exercise increased endogenous MOTS-c in muscle and circulation in the human component.