Study record · MOTS-c
MOTS-c is an exercise-induced mitochondrial-encoded regulator of physical decline
Exercise increased endogenous MOTS-c in muscle and circulation in the human component.
Key result
Exercise increased endogenous MOTS-c in muscle and circulation in the human component.
Study details
Study designHuman endogenous biomarker substudy plus extensive preclinical experiments
PopulationYoung male exercise participants in human component
Sample size10
RouteNo exogenous MOTS-c administration in humans
Regimen / exposureStationary bicycle exercise with muscle and blood sampling
DurationAcute exercise
ComparatorPre/post exercise
Primary endpoint / questionEndogenous skeletal-muscle and circulating MOTS-c response to exercise
Safety resultNot a drug-exposure safety study.
Key limitationsEndogenous peptide response is not evidence that injected/supplemented MOTS-c is effective or safe in humans.
Registry / identifierPMID 33473109