Registered human trial · no results posted · MOTS-c
MOTS-MET: MOTS-c for insulin sensitivity in adults with prediabetes and overweight/obesity
Recruiting; no results posted as of this review.
Quick read
Registered human trial — no results yet
What this study tells us
This is a registered, recruiting randomized human trial. The registry describes the planned population, treatment period and endpoints, but no outcome results were posted at the last review. Registration alone does not establish benefit or safety.
Who was studied?
Adults 18-65 with prediabetes and BMI 27-40
How many?
120 participants planned
What happened?
No results posted as of the last evidence review; recruitment was ongoing.
What stops us overclaiming?
Trial registration proves prospective human development, not efficacy or established safety.
Need help with terms such as randomized, placebo, endpoint or sample size? Open the glossary →
Key result
Recruiting; no results posted as of this review.
Study details
Study designRandomized, double-blind, placebo-controlled clinical trial
PhasePhase 2a
PopulationAdults 18-65 with prediabetes and BMI 27-40
Sample size120 planned
RouteSubcutaneous
Regimen / exposureFixed dose once daily for 12 weeks; public registry does not state the dose
Duration12 weeks + safety follow-up to week 16
ComparatorPlacebo
Primary endpoint / questionOGTT-derived insulin sensitivity plus metabolic and safety endpoints
Safety resultSafety is a co-primary/primary focus; no public outcome data yet.
Key limitationsTrial registration proves prospective human development, not efficacy or established safety.
Registry / identifierNCT07505745