Human evidence record · MOTS-c
MOTS-c response to acute exercise in humans
Human physiology study measured endogenous MOTS-c; it was not a therapeutic administration trial.
Quick read
Human evidence record
What this study tells us
This was a human pharmacology or physiology study. It can show what the compound does to measured biological signals, but it may not establish a meaningful clinical benefit.
Who was studied?
Adults assigned to exercise/physiology testing
How many?
n=30
What happened?
Human physiology study measured endogenous MOTS-c; it was not a therapeutic administration trial.
What stops us overclaiming?
Endogenous biomarker behaviour cannot establish effects, dose, or safety of injected/synthetic MOTS-c.
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Key result
Human physiology study measured endogenous MOTS-c; it was not a therapeutic administration trial.
Study details
Study designRandomized exercise physiology study
PopulationAdults assigned to exercise/physiology testing
Sample size30
RouteEndogenous measurement
Regimen / exposureNo exogenous MOTS-c administered
DurationAcute exercise
ComparatorExercise/control conditions
Primary endpoint / questionCirculating/endogenous MOTS-c response
Safety resultNot an exogenous safety study.
Key limitationsEndogenous biomarker behaviour cannot establish effects, dose, or safety of injected/synthetic MOTS-c.
Registry / identifierPMID 34351816