Study record · Modified GRF(1-29) / 'CJC without DAC'
D-Ala2 GHRH(1-29) pharmacokinetics in normal men
D-Ala2 substitution reduced metabolic clearance and increased disappearance half-time from 4.3 to 6.7 minutes.
Key result
D-Ala2 substitution reduced metabolic clearance and increased disappearance half-time from 4.3 to 6.7 minutes.
Study details
Study designHuman pharmacokinetic comparative study
PopulationNormal men
Sample size10
RouteIntravenous infusion
Regimen / exposureD-Ala2-GHRH(1-29)-NH2 at 25 ng/kg/min for 90 minutes
Duration90 minutes + washout sampling
ComparatorNative GHRH(1-29)-NH2
Primary endpoint / questionMetabolic clearance and half-time
Safety resultNo major adverse effects highlighted in the abstract.
Key limitationsThis is a single-substitution GHRH analogue, not the four-substitution marketplace Modified GRF(1-29); it is mechanistic context only.
Registry / identifierPMID 7962295