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Human evidence record ยท Kisspeptin

Kisspeptin administration in women with hypoactive sexual desire disorder

Kisspeptin modulated sexual/emotional brain processing; 32 participants completed evaluable crossover testing.

Quick read
Human evidence record

What this study tells us

Participants were assigned to comparison groups by chance, usually with placebo and/or blinding to reduce bias. This is a strong design for testing cause and effect, but the population, duration and endpoints still limit what can be concluded.

Who was studied?

Women with HSDD

How many?

n=40

What happened?

Kisspeptin modulated sexual/emotional brain processing; 32 participants completed evaluable crossover testing.

What stops us overclaiming?

Short mechanistic study; not a long-term clinical-outcome trial.

Need help with terms such as randomized, placebo, endpoint or sample size? Open the glossary โ†’

Key result

Kisspeptin modulated sexual/emotional brain processing; 32 participants completed evaluable crossover testing.

Study details

Study designRandomized double-blind placebo-controlled crossover study
PopulationWomen with HSDD
Sample size40
RouteIntravenous infusion
Regimen / exposureKisspeptin-54 at 1 nmol/kg/hour
Duration75 minutes
ComparatorPlacebo
Primary endpoint / questionSexual brain processing and psychometric responses
Safety resultNo major acute adverse effects reported.
Key limitationsShort mechanistic study; not a long-term clinical-outcome trial.
Registry / identifierPMID 36287566