WhichPepsPeptides. Without the hype.
Human evidence record ยท Kisspeptin

Kisspeptin administration in men with hypoactive sexual desire disorder

Kisspeptin altered sexual/emotional brain processing and increased penile tumescence in experimental conditions.

Quick read
Human evidence record

What this study tells us

Participants were assigned to comparison groups by chance, usually with placebo and/or blinding to reduce bias. This is a strong design for testing cause and effect, but the population, duration and endpoints still limit what can be concluded.

Who was studied?

Men with HSDD

How many?

n=37

What happened?

Kisspeptin altered sexual/emotional brain processing and increased penile tumescence in experimental conditions.

What stops us overclaiming?

Small mechanistic study; short exposure; does not establish long-term clinical efficacy or a routine treatment regimen.

Need help with terms such as randomized, placebo, endpoint or sample size? Open the glossary โ†’

Key result

Kisspeptin altered sexual/emotional brain processing and increased penile tumescence in experimental conditions.

Study details

Study designRandomized double-blind placebo-controlled crossover study
PopulationMen with HSDD
Sample size37
RouteIntravenous infusion
Regimen / exposureKisspeptin-54 at 1 nmol/kg/hour
Duration75 minutes
ComparatorPlacebo
Primary endpoint / questionSexual brain processing and physiological arousal
Safety resultNo major acute safety signal reported in the paper.
Key limitationsSmall mechanistic study; short exposure; does not establish long-term clinical efficacy or a routine treatment regimen.
Registry / identifierPMID 36735255