Human evidence record · Hexarelin
Hexarelin decreases slow-wave sleep and stimulates multiple hormones during sleep
Hexarelin reduced stage-4/slow-wave-related sleep measures while increasing GH, prolactin, ACTH and cortisol.
Quick read
Human evidence record
What this study tells us
This was a human pharmacology or physiology study. It can show what the compound does to measured biological signals, but it may not establish a meaningful clinical benefit.
Who was studied?
Healthy young volunteers
How many?
n=7
What happened?
Hexarelin reduced stage-4/slow-wave-related sleep measures while increasing GH, prolactin, ACTH and cortisol.
What stops us overclaiming?
Very small acute study.
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Key result
Hexarelin reduced stage-4/slow-wave-related sleep measures while increasing GH, prolactin, ACTH and cortisol.
Study details
Study designPlacebo-controlled sleep/endocrine study
PopulationHealthy young volunteers
Sample size7
RouteInjection
Regimen / exposureFour 50 microg administrations overnight
DurationOvernight
ComparatorPlacebo
Primary endpoint / questionSleep EEG and nocturnal endocrine profiles
Safety resultHighlights a potential sleep/endocrine trade-off rather than a simple recovery effect.
Key limitationsVery small acute study.
Registry / identifierPMID 15177700