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Human evidence record · Hexarelin

Hexarelin-induced GH, cortisol and prolactin release: dose-response study

Hexarelin produced dose-dependent GH and prolactin responses and a cortisol increase at higher doses; low-dose hexarelin was synergistic with GHRH for GH release.

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Human evidence record

What this study tells us

This was a human pharmacology or physiology study. It can show what the compound does to measured biological signals, but it may not establish a meaningful clinical benefit.

Who was studied?

Healthy adult men

How many?

n=Small study

What happened?

Hexarelin produced dose-dependent GH and prolactin responses and a cortisol increase at higher doses; low-dose hexarelin was synergistic with GHRH for GH release.

What stops us overclaiming?

Acute small study; no evidence for long-term performance, recovery or anti-ageing benefit.

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Key result

Hexarelin produced dose-dependent GH and prolactin responses and a cortisol increase at higher doses; low-dose hexarelin was synergistic with GHRH for GH release.

Study details

Study designDose-response human physiology study
PopulationHealthy adult men
Sample sizeSmall study
RouteIntravenous
Regimen / exposure0–1.0 microg/kg; additional GHRH combination condition
DurationSingle exposure
ComparatorDose conditions / GHRH
Primary endpoint / questionGH, prolactin and cortisol responses
Safety resultNon-GH endocrine activation is clinically relevant.
Key limitationsAcute small study; no evidence for long-term performance, recovery or anti-ageing benefit.
Registry / identifierPMID 8954038