Human evidence record · GHRP-6
GHRP-6 stimulates sleep, GH, ACTH and cortisol release in normal men
GHRP-6 increased GH, ACTH, cortisol and stage-2 sleep; slow-wave sleep was unchanged.
Quick read
Human evidence record
What this study tells us
This was a human pharmacology or physiology study. It can show what the compound does to measured biological signals, but it may not establish a meaningful clinical benefit.
Who was studied?
Healthy men
How many?
n=Small study
What happened?
GHRP-6 increased GH, ACTH, cortisol and stage-2 sleep; slow-wave sleep was unchanged.
What stops us overclaiming?
Small old physiology study; no evidence for durable sleep treatment or physique benefit.
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Key result
GHRP-6 increased GH, ACTH, cortisol and stage-2 sleep; slow-wave sleep was unchanged.
Study details
Study designPlacebo-controlled sleep/endocrine physiology study
PopulationHealthy men
Sample sizeSmall study
RouteIntravenous
Regimen / exposureFour 50 microg boluses during the night
DurationOvernight
ComparatorPlacebo
Primary endpoint / questionSleep EEG plus GH, ACTH and cortisol secretion
Safety resultACTH/cortisol stimulation shows endocrine effects beyond GH.
Key limitationsSmall old physiology study; no evidence for durable sleep treatment or physique benefit.
Registry / identifierPMID 7617137