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Human evidence record · GHRP-6

Route-dependent sleep/endocrine effects of GHRP-6

Oral dosing did not change GH/ACTH/cortisol; intranasal dosing increased GH and showed route-dependent endocrine/sleep effects.

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Human evidence record

What this study tells us

This was a human pharmacology or physiology study. It can show what the compound does to measured biological signals, but it may not establish a meaningful clinical benefit.

Who was studied?

Healthy young men

How many?

n=Small study

What happened?

Oral dosing did not change GH/ACTH/cortisol; intranasal dosing increased GH and showed route-dependent endocrine/sleep effects.

What stops us overclaiming?

Small acute study; old formulation-specific data and no therapeutic clinical outcomes.

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Key result

Oral dosing did not change GH/ACTH/cortisol; intranasal dosing increased GH and showed route-dependent endocrine/sleep effects.

Study details

Study designPlacebo-controlled route-comparison physiology study
PopulationHealthy young men
Sample sizeSmall study
RouteOral / intranasal / sublingual
Regimen / exposure300 microg/kg oral; 30 microg/kg intranasal or sublingual
DurationOvernight
ComparatorPlacebo conditions
Primary endpoint / questionGH, ACTH, cortisol and sleep effects by route
Safety resultRoute materially changed biological activity.
Key limitationsSmall acute study; old formulation-specific data and no therapeutic clinical outcomes.
Registry / identifierPMID 10336729
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