Human evidence record · GHK-Cu
Topical copper tripeptide after CO2 laser resurfacing
No significant objective benefit versus vehicle; subjective satisfaction favored copper-tripeptide (P=.04).
Quick read
Human evidence record
What this study tells us
Participants were assigned to groups by chance, which helps reduce selection bias. The exact comparator, blinding, population and endpoint still matter when judging the result.
Who was studied?
Adults undergoing CO2 laser resurfacing
How many?
n=13
What happened?
No significant objective benefit versus vehicle; subjective satisfaction favored copper-tripeptide (P=.04).
What stops us overclaiming?
Very small sample; topical formulation only; subjective result diverged from objective outcomes.
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Key result
No significant objective benefit versus vehicle; subjective satisfaction favored copper-tripeptide (P=.04).
Study details
Study designRandomized controlled topical study
PopulationAdults undergoing CO2 laser resurfacing
Sample size13
RouteTopical
Regimen / exposure0.4% copper-tripeptide cream
DurationPost-procedure follow-up
ComparatorVehicle/control cream
Primary endpoint / questionObjective erythema, wrinkles and overall skin quality
Safety resultNo major safety signal highlighted in abstract.
Key limitationsVery small sample; topical formulation only; subjective result diverged from objective outcomes.
Registry / identifierPMID 16847171