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Human evidence record · Delta sleep-inducing peptide

Double-blind DSIP study in chronic insomnia

Some objective signals occurred, but effects were weak/inconsistent and investigators considered major therapeutic benefit unlikely.

Quick read
Human evidence record

What this study tells us

This study compared groups, which is more informative than an uncontrolled report. The amount of confidence still depends on how the groups were formed, how outcomes were measured and how well bias was controlled.

Who was studied?

People with chronic insomnia

How many?

n=16

What happened?

Some objective signals occurred, but effects were weak/inconsistent and investigators considered major therapeutic benefit unlikely.

What stops us overclaiming?

Very small, old trial; outdated methods and limited replication.

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Key result

Some objective signals occurred, but effects were weak/inconsistent and investigators considered major therapeutic benefit unlikely.

Study details

Study designDouble-blind controlled clinical study
PopulationPeople with chronic insomnia
Sample size16
RouteIntravenous
Regimen / exposure25 nmol/kg before nights 3-5
DurationSeveral nights
ComparatorPlacebo/control
Primary endpoint / questionSleep architecture and subjective sleep
Safety resultNo robust modern safety dataset established.
Key limitationsVery small, old trial; outdated methods and limited replication.
Registry / identifierPMID 1299794