Study record · Cerebrolysin
Cerebrolysin enhances cognitive recovery of mild traumatic brain injury patients
CASI improvement from baseline to week 12 was greater with Cerebrolysin (21.0 vs 7.6; p=0.0461).
Key result
CASI improvement from baseline to week 12 was greater with Cerebrolysin (21.0 vs 7.6; p=0.0461).
Study details
Study designDouble-blind, placebo-controlled randomized pilot
PhasePhase 2 pilot
PopulationAdults with acute mild TBI and intracranial contusion haemorrhage
Sample size32
RouteIntravenous
Regimen / exposure30 mL daily over 60 min for 5 days
Duration5 days; follow-up to week 12
ComparatorNormal saline
Primary endpoint / questionMMSE/CASI cognitive recovery
Safety resultSmall pilot reported no major safety signal highlighted in abstract.
Key limitationsVery small N; multiple cognitive domains; borderline primary comparison; requires replication.
Registry / identifierPMID 23656173