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Review / evidence synthesis · Cerebrolysin

Cerebrolysin for acute ischaemic stroke — Cochrane review

Moderate-certainty evidence found no beneficial effect on all-cause death; non-death attrition evidence very uncertain.

Quick read
Review / evidence synthesis

What this study tells us

This study reviewed or combined evidence from multiple studies. It can show the overall direction of a field, but its conclusion still depends on the quality and relevance of the studies it included.

Who was studied?

Adults with acute ischaemic stroke

How many?

n=Multiple trials; SAE analysis 1335

What happened?

Moderate-certainty evidence found no beneficial effect on all-cause death; non-death attrition evidence very uncertain.

What stops us overclaiming?

Heterogeneous peptide mixtures/trials; clinical outcome data limited; indication-specific.

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Key result

Moderate-certainty evidence found no beneficial effect on all-cause death; non-death attrition evidence very uncertain.

Study details

Study designSystematic review / meta-analysis of RCTs
PhaseNot applicable
PopulationAdults with acute ischaemic stroke
Sample sizeMultiple trials; SAE analysis 1335
RouteIntravenous
Regimen / exposureVaried; subgroup included 30 mL for 10 days
DurationAcute treatment trials
ComparatorPlacebo / usual care
Primary endpoint / questionMortality, adverse events and functional outcomes
Safety resultTotal SAEs little/no difference, but non-fatal SAEs increased: RR 2.39 (95% CI 1.10–5.23) in 3 trials.
Key limitationsHeterogeneous peptide mixtures/trials; clinical outcome data limited; indication-specific.
Registry / identifierCochrane review