Study record · BPC-157 + TB-500 blend
BPC-157 + TB-500 combination arm in rat Achilles tendon repair
The combination improved some histologic measures versus control but did not provide additional benefit over either agent alone.
Key result
The combination improved some histologic measures versus control but did not provide additional benefit over either agent alone.
Study details
Study designRandomized animal experiment
PhasePreclinical
PopulationMale Sprague-Dawley rats after Achilles tendon transection and repair
Sample size32
RouteIntraperitoneal
Regimen / exposureBPC-157 10 microg/kg/day + TB-500 60 microg/kg/day in the combination arm
Duration4 weeks
ComparatorControl and each monotherapy
Primary endpoint / questionBiomechanics, histology and whether the combination adds benefit
Safety resultNo human combination safety evidence was generated.
Key limitationsExploratory animal study; does not establish human synergy, dosing or safety.
Registry / identifierPMID 42542926