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Animal / preclinical evidence ยท BPC-157 + TB-500 blend

BPC-157 + TB-500 combination arm in rat Achilles tendon repair

The combination improved some histologic measures versus control but did not provide additional benefit over either agent alone.

Quick read
Animal / preclinical evidence

What this study tells us

This was preclinical research in animals and/or laboratory models. It can show a biological signal, but it cannot prove the same benefit, dose or safety in people.

Who was studied?

Male Sprague-Dawley rats after Achilles tendon transection and repair

How many?

n=32

What happened?

The combination improved some histologic measures versus control but did not provide additional benefit over either agent alone.

What stops us overclaiming?

Exploratory animal study; does not establish human synergy, dosing or safety.

Need help with terms such as randomized, placebo, endpoint or sample size? Open the glossary โ†’

Key result

The combination improved some histologic measures versus control but did not provide additional benefit over either agent alone.

Study details

Study designRandomized animal experiment
PhasePreclinical
PopulationMale Sprague-Dawley rats after Achilles tendon transection and repair
Sample size32
RouteIntraperitoneal
Regimen / exposureBPC-157 10 microg/kg/day + TB-500 60 microg/kg/day in the combination arm
Duration4 weeks
ComparatorControl and each monotherapy
Primary endpoint / questionBiomechanics, histology and whether the combination adds benefit
Safety resultNo human combination safety evidence was generated.
Key limitationsExploratory animal study; does not establish human synergy, dosing or safety.
Registry / identifierPMID 42542926