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Human evidence record ยท Semax

Semax in the acute period of hemispheric ischemic stroke

Semax added to intensive therapy was reported to accelerate regression of neurological deficits, especially motor impairment.

Quick read
Human evidence record

What this study tells us

This study compared groups, which is more informative than an uncontrolled report. The amount of confidence still depends on how the groups were formed, how outcomes were measured and how well bias was controlled.

Who was studied?

Patients with acute hemispheric ischemic stroke

How many?

n=Not stated in search extract

What happened?

Semax added to intensive therapy was reported to accelerate regression of neurological deficits, especially motor impairment.

What stops us overclaiming?

Older regional controlled study; methods and endpoints are not described to contemporary trial-reporting standards in the accessible abstract.

Need help with terms such as randomized, placebo, endpoint or sample size? Open the glossary โ†’

Key result

Semax added to intensive therapy was reported to accelerate regression of neurological deficits, especially motor impairment.

Study details

Study designControlled comparative clinical study
PopulationPatients with acute hemispheric ischemic stroke
Sample sizeNot stated in search extract
RouteClinical Semax formulation
Regimen / exposureDaily doses reported as 12 mg for moderate stroke and 18 mg for severe stroke
Duration5-10 days
ComparatorCombined intensive therapy without Semax
Primary endpoint / questionNeurological functional recovery and electrophysiologic measures
Safety resultModern systematic safety reporting was limited.
Key limitationsOlder regional controlled study; methods and endpoints are not described to contemporary trial-reporting standards in the accessible abstract.
Registry / identifierPMID 11517472