Ipamorelin for postoperative ileus after bowel resection
Median time was 25.3 hours with ipamorelin versus 32.6 hours placebo; difference was not statistically significant (P=0.15). Key and secondary efficacy analyses were not significant.
What this study tells us
Participants were assigned to comparison groups by chance, usually with placebo and/or blinding to reduce bias. This is a strong design for testing cause and effect, but the population, duration and endpoints still limit what can be concluded.
Adults undergoing small or large bowel resection
n=117 enrolled; 114 safety/mITT
Median time was 25.3 hours with ipamorelin versus 32.6 hours placebo; difference was not statistically significant (P=0.15). Key and secondary efficacy analyses were not significant.
Post-surgical inpatient population and IV route; cannot be extrapolated to subcutaneous wellness/bodybuilding use.
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Key result
Median time was 25.3 hours with ipamorelin versus 32.6 hours placebo; difference was not statistically significant (P=0.15). Key and secondary efficacy analyses were not significant.